Unproductive splicing of SR genes associated with highly- and ultraconserved DNA elements
نویسندگان
چکیده
I. Supplementary methods and results ........................................................................S1 II. Supplementary figures (5) .......................................................................................S7 III. Supplementary tables (5)........................................................................................S12 IV. Supplementary notes (literature cited) .................................................................S17
منابع مشابه
Regulation of Splicing Factors by Alternative Splicing and NMD Is Conserved between Kingdoms Yet Evolutionarily Flexible
Ultraconserved elements, unusually long regions of perfect sequence identity, are found in genes encoding numerous RNA-binding proteins including arginine-serine rich (SR) splicing factors. Expression of these genes is regulated via alternative splicing of the ultraconserved regions to yield mRNAs that are degraded by nonsense-mediated mRNA decay (NMD), a process termed unproductive splicing (L...
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